Apoorva Kalasuramath-Salimath

Georgia Tech

Mechanical Engineering

BioEngineering

PhD Candidate

Lab Website

Personal or Affiliate Website

Garcia Lab

Hydrogel-based Skeletal Muscle Force Actuators

Alignment and differentiation of skeletal progenitor monolayers into myotubes has been achieved on a variety of synthetic scaffolds, while functionality of 3D skeletal muscle constructs has been limited to biological scaffolds. The purpose of this research project is to engineer a 3D microenvironment, using synthetic, polymer-based hydrogels, to promote the development of differentiated muscle tissue from skeletal muscle progenitor cells to form contractile units. We hypothesize that by modulating controllable hydrogel properties we can create critical environmental features and modes of interaction to promote attachment, proliferation and differentiation for the stable formation of multinucleated myotubes and consequently, functional skeletal muscle tissue constructs.Alignment and differentiation of skeletal progenitor monolayers into myotubes has been achieved on a variety of synthetic scaffolds, while functionality of 3D skeletal muscle constructs has been limited to biological scaffolds. The purpose of this research project is to engineer a 3D microenvironment, using synthetic, polymer-based hydrogels, to promote the development of differentiated muscle tissue from skeletal muscle progenitor cells to form contractile units. We hypothesize that by modulating controllable hydrogel properties we can create critical environmental features and modes of interaction to promote attachment, proliferation and differentiation for the stable formation of multinucleated myotubes and consequently, functional skeletal muscle tissue constructs.

 

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